Application of PVP in drug delivery
Polyvinylpyrrolidone (PVP) plays a vital role in drug delivery systems due to its unique physical and chemical properties. PVP can significantly enhance the solubility and bioavailability of poorly soluble drugs by forming solid dispersions or complexes. For example, in the preparation of naproxen, PVP is used to form a solid dispersion, which greatly improves the dissolution rate and stability of the drug. Similarly, PVP is also widely used in the preparation of drugs such as indomethacin and chloramphenicol to ensure that these drugs can be effectively absorbed in the body.
In addition to enhancing the solubility of drugs, PVP is also widely used in drug release systems. It is used to prepare controlled-release tablets, transdermal patches, and eye drops to control the rate of drug release. For example, PVP nanofibers prepared through electrospinning technology can achieve sustained release and local delivery of drugs due to their high specific surface area and controllable pore structure. This kind of nanofiber has been used in the delivery system of a variety of drugs, such as local sustained-release systems for aspirin and ibuprofen, which greatly improves the efficacy of the drug and reduces side effects.