Crosslinked povidone is a water insoluble tablet disintegrant, which can quickly show high capillary activity and excellent hydration ability, almost without gel tendency; Research has shown that the size of cross-linked polyvinylpyrrolidone particles strongly affects the disintegration of antipyretic and analgesic tablets, with larger cross-linked polyvinylpyrrolidone particles exhibiting faster disintegration compared to smaller ones. Crosslinked polyvinylketone is a very excellent disintegrant, with a dosage of 1-2% in tablets, which can achieve the disintegration effect of other commonly used ordinary disintegrants, known as super disintegrants.
Crosslinked polyvinylpyrrolidone can also be used as a dry adhesive, filler, and excipient for tablets, capsules, and granules. Its smaller particle size can reduce the spots on the tablet surface and improve the uniformity of the tablet. The commonly used dosage is 20-80mg/tablet.
Crosslinked polyvinylpyrrolidone can also be used as a dissolution promoter. Co evaporation technology can increase the solubility of poorly soluble drugs: first, appropriate solvents are adsorbed onto cross-linked polyvinylpyrrolidone, and then the solvent is evaporated. This technology can achieve a faster dissolution rate.
This product is also widely used as a filter aid in the food industry for brewing and vinegar production, to remove enzymes and proteins.
Crosslinked polyvinylketone and polyphenols can form stable complexes, which can be used to refine water-soluble or alcohol containing herbal extracts and tinctures, improving the stability of plant medicine.